High prevalence of metabolic syndrome in populations at high and low cardiovascular risk in Bulgaria
T. Temelkova-Kurktschiev, D. Kurktschiev, L. Vladimirova-Kitova, I. Vaklinova, P.Bonov
Abstract:
Objective:
Metabolic syndrome (MetS) is associated with cardiovascular risk. We examined the prevalence of MetS in well-defined groups with manifested cardiovascular disease (CVD) or at high CVD risk, and in a low-risk population. We also analysed the CVD burden of the MetS in these populations.
Methods:
A total of 2123 subjects were examined: 1.with history of acute myocardial infarction (AMI) (n=372); 2.with hypertension (n=620); 3.with type 2 diabetes mellitus (n=556) and 4.healthy controls (n=575). All participants underwent standardised examination of cardiovascular risk.
Results:
The prevalence of the MetS was: 80% in men and 89% in women according to the Adult Treatment Panel III (ATPIII) definition, 85% in men and 93% in women according to the International Diabetes Federation (IDF) definition in the AMI group; 43% in men and 53% in women (ATPIII criteria), 47% in men and 61% in women (IDF criteria) in the hypertensive group; 70% in men and 79% in women (ATPIII), 77% in men and 86% in women (IDF) in the diabetic patients; and 23% in men and women (ATPIII), 30% in men and 36% in women (IDF criteria) in the controls. In logistic regression analysis the presence of MetS was found an independent determinant of previous AMI in the examined population.
Conclusion:
Excessively high prevalence of MetS was found in populations with or at high CVD risk, and a high prevalence even in a low-risk group in Bulgaria. The presence of MetS increased CVD risk.
Keywords:
Metabolic syndrome, Cardiovascular risk, Type 2 diabetes mellitus, Hyper/dyslipidemia