• Users Online: 721
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2010  |  Volume : 1  |  Issue : 2  |  Page : 3

Assessment of the risk for metabolic syndrome in prediabetes and newly-diagnosed type 2 diabetes


1 Department of Diabetology, Clinical Centre of Endocrinology, Medical University, Sofia, Bulgaria
2 New Bulgarian University, Sofia, Bulgaria

Correspondence Address:
T I Tankova
Associate Professor, Clinical Centre of Endocrinology University Hospital of Endocrinology Medical University, Sofia 12, Narodno Sabranie sq. 1000 - Sofia, Bulgaria

Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

The aim of the present study was to assess the risk for metabolic syndrome (MetS) in subjects with pre- diabetes - impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and in newly- diagnosed type 2 diabetes (NDD). The metabolic syndrome parameters (according to 2005 IDF definition) and high-sensitive C-reactive protein (hsCRP) were measured in 727 subjects - 238 with IFG, 184 with IGT and 305 with NDD. The unadjusted prevalence of MetS was 84.03% in IFG, 89.13% in IGT and 89.51% in NDD. The odds ratio (OR) for prevalent MetS was 8.82 (95% CI, 3.19 -19.8, p<0.001) in IFG, 11.26 (95% CI, 4.18 -24.6, p<0.001) in IGT and 4.87 (95% CI, 2.10 -9.50, p<0.001) in NDD. Of the different studied parameters, the OR for metabolic syndrome was significant for female sex - 2.31 (95% CI, 1.45-4.35, p=0.009), fasting plasma glucose - 2.30 (95% CI, 1.56 -3.40, p<0.001), waist circumference - 1.36 (95% CI, 1.12-1.42, p<0.001), HDL -cholesterol - 0.273 (95% CI, 0.14-0.52, p=0.01) and triglycerides - 3.84 (95% CI, 2.61-5.66, p<0.0001). Significantly higher hsCRP level s were found in all groups with MetS as compared to those without MetS. The prevalence of MetS in pre-diabetes is rather high, being similar to that in newly-diagnosed type 2 diabetes. The risk for MetS is even higher in pre-diabetes as compared to NDD. Therefore IFG and IGT should be considered not just as conditions of altered glucose metabolism but also in relation to their association with cardiovascular risk factors.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1461    
    Printed123    
    Emailed0    
    PDF Downloaded182    
    Comments [Add]    

Recommend this journal