• Users Online: 64
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 2  |  Page : 2

A ntihyperglycemic and antihyperlipidemic activity of Urtica dioicaon type 2 diabetic model rats


1 Govt. Ayurvedic College and Hospital, Guwahati-14, Assam, India; Department of Pharmacology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh
2 Govt. Ayurvedic College and Hospital, Guwahati-14, Assam, India
3 Department of Pharmacology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh
4 Department of Biochemistry & Molecular Biology, University of Chittagong, Bangladesh
5 Department of Chemistry, University of Dhaka, Bangladesh
6 Department of Gastroenterology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh
7 Department of Biochemistry and Cell Biology, Bangladesh Institute of Research and Rehabi- litation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh

Correspondence Address:
M Das
Department of Pharmacology, Bangladesh

Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

The aim of this study was to explore the effects of the aqueous extract of Urtica dioica (UD) on glycemic status, body weight and lipidemic status in type 2 diabetic model rats. The mature and fresh leaves of UD were collected from the mountain range of Assam, in India. Type 2 diabetes was induced in 48 hour old male Long Evans pups by a single intraperitoneal (IP) injection of Streptozotocin (STZ). Experiments for chronic effects were done with continuous feeding of aqueous extract for 28 days at a dose of 1.25 g/kg body weight, in type 2 diabetic male rats. Serum glucose was estimated by GOD- POD method. Serum triglycerides and cholesterol were measured by enzymatic-colorimetric method. The aqueous extract showed significant effect on lowering of fasting serum glucose levels on the 28th day (13.7 ±2.6 mmol/l in control vs 7.1 ± 1.0 mmol/l in the treated group, p = 0.01). Body weights was increased in both the groups, after 28 days, although there was significant decrease in the body weight of the treated group in comparison to the control group (175 ± 8 g in control vs in 168 ± 9 g in the treated group on 0 day, p = ns; 193 ± 26 g in control vs in 180 ± 25 g in the treated group on the 28th day, p=0.002). Beneficial effects were observed on the lipids; cholesterol levels were significantly lowered in the extract treated group, after 28 days, in comparison with the 0 day value of the same group (p<0.05). Triglyceride and LDL values were lower in extract treated group, although the values were not statistically significant. The results obtained in this study suggest that UD has anti- hyperglycemic and anti-hyperlipidemic activity in type 2 diabetic model rats.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed810    
    Printed82    
    Emailed0    
    PDF Downloaded210    
    Comments [Add]    

Recommend this journal