• Users Online: 122
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 2  |  Page : 4

Anti-diabetic effect of Rubus ellipticus fruit extracts in alloxan induced diabetic rats


1 Department of Pharmacology, Sir Madanlal Institute of Pharmacy, Alampur Hauz, Agra Road. Etawah, Uttar Pradesh; Department of Pharmaceutical Science, Jodhpur National University, Jhanwar Road, Narnadi, Jodhpur, Rajasthan, India
2 Department of Pharmacy, Mahila Vishwavidyalya, Khanpur Kalan, Sonipat, Harayana, India

Correspondence Address:
U S Sharma
Department of Pharmacology, Sir Madanlal Institute of Pharmacy, Alampur Hauz, Agra Road. Etawah, Uttar Pradesh; Department of Pharmaceutical Science, Jodhpur National University, Jhanwar Road, Narnadi, Jodhpur, Rajasthan, India

Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Alloxan (2, 4, 5, 6-tetraoxypyrimidine; 2, 4, 5, 6-pyrimidinetetrone) is a toxic glucose analogue, which selectively destroys insulin-producing pancreatic β-cells and causes a non-insulin-dependent diabetes mellitus (NIDDM), when administered to animal species. In this study, the protective effects of Rubus ellipticus fruit on glucose tolerance test and an alloxan induced diabetes were evaluated. An effort was also made to investigate the acute toxicity (LD50) of the extracts and the qualitative presence of phytoconstituents in the extracts. Male wistar albino rats of either sex (weighing 150-200 g) were studies for glucose tolerance test and alloxan induced diabetes. Pet.ether, ethanolic and aqueous extracts of Rubus ellipticus fruit were selected for anti-diabetic activity. Blood glucose levels were estimated at different time intervals on 1st, 4th, 7th and 15th day of the treatment with Rubus ellipticus extracts and glibenclamide. These levels were compared with these of the diabetic control group. Phytochemical analysis of Rubus ellipticus fruit revealed the presence of flavonoids, carbohydrates, steroids, tannins and phenolic compounds. In acute toxicity study, no toxic neurological and behavioral symptoms were observed for the titled plant extracts up to a dose of 2000 mg/kg. All the extracts of Rubus ellipticus fruit exhibited significant anti-diabetic effect in both the experimental models of diabetes mellitus. The results justified the traditional use of fruits in the treatment of diabetes.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1259    
    Printed75    
    Emailed1    
    PDF Downloaded337    
    Comments [Add]    

Recommend this journal