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ORIGINAL ARTICLE
Year : 2012  |  Volume : 3  |  Issue : 1  |  Page : 4

Electro physiological assessment of neuropathy in visual pathway of diabetes mellitus


Department of Physiology, Meenakshi Medical College and Hospital, Enathur, Kanchipuram, Tamilnadu, India

Correspondence Address:
M Chandrasekhar
Head of Department, Department of Physiology, Meenakshi Medical College and Hospital, Enathur, Kanchipuram, Tamilnadu, India

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Source of Support: None, Conflict of Interest: None


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Visual deficit is normally an end-stage sign of both vascular and metabolic abnormalities in Diabetes Mellitus which can affect the retina and the visual pathways. The aim of this study was to find whether the VEP latencies are altered in diabetics and if altered, whether it shows any correlation with the glycemic control and duration of diabetes. A case control study included 40 type 2 diabetic patients with age and sex matched 20 controls. All subjects were investigated for Fasting blood glucose (FBG), Post prandial blood sugar (PPBS), Glycosylated haemoglobin (HbA1C) and also underwent neurological and ophthalmological examination. Visual evoked potentials were recorded through using pattern reversal stimulation, using a checkerboard by placing 3 scalp electrodes i.e. Frontal (FPZ), Occipital (OZ) and grounding (CZ). The P100 and N75 latencies and amplitudes were studied. There was a prolongation of P100 and N75 latencies and a decrease in amplitude of VEP in diabetes mellitus group, when compared with the control group. The subjects with poor metabolic control showed an increase in latencies, when compared with the subjects having good metabolic control. It was observed that there was a prolongation in VEP latencies and reduction in amplitude in diabetic group as the duration increased. The anterior visual pathway seemed to have functional disturbance before the development of retinopathy in diabetic patients. VEP is a very sensitive method for evaluating the central visual pathway impairment in DM and is also recommended for a proper management of this metabolic illness, which can lead to blindness.


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