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ORIGINAL ARTICLE
Year : 2012  |  Volume : 3  |  Issue : 1  |  Page : 5

Low ghrelin level is associated with poor control and bad prognosis parameters in obese diabetic patients


Department of Chemistry, College of Science, Kufa University, Iraq

Correspondence Address:
H K Al-Hakeim
Department of Chemistry, College of Science, Kufa University, Iraq

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Source of Support: None, Conflict of Interest: None


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High ghrelin level is associated with increased appetite. Type 2 diabetes mellitus also has an association with increased appetite. However, many researchers have found low ghrelin levels in diabetic patients. To look into this controversy, the present study aimed to assess the ghrelin hormone levels in obese diabetic patients and correlate its level with different parameters including lipid profile, glycated hemoglobin (HbA1c), insulin resistance (IR) parameters calculated from Homeostasis Model Assessment Insulin Resistance (HOMA-IR), HOMA insulin sensitivity (HOMA2-%S), and HOMA beta cells function (HOMA2-%B). It was a cross sectional study in which sixty obese type 2 diabetic patients and 30 control subjects participated. Biochemical parameters were measured spectrophotometrically except ghrelin and insulin levels which were measured by using ELISA technique. HbA1c concentration was measured by ion-exchange chromatography. Insulin resistance parameters were calculated using HOMA 2 calculator software. Mean ghrelin levels were low in obese diabetic patients and non-IR patients had moderately higher ghrelin levels than IR patients. Ghrelin levels were negatively correlated with BMI, cholesterol, HbA1c, atherogenic ratios, and HOMA 2 - % S. Ghrelin levels were positively correlated with HDL-C and HOMA 2 IR. Regression analysis produced the equation which correlated the ghrelin level with the parameters of obesity, the risk of atherosclerosis, and insulin resistance parameters. It can be concluded that low ghrelin level is associated with poor diabetes control and bad prognosis parameters in obese diabetic patients.


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