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ORIGINAL ARTICLE
Year : 2013  |  Volume : 4  |  Issue : 1  |  Page : 4

Relationship of oxidative stress with type 2 diabetes and hypertension


1 Department of Biology, Nigerian Turkish international Colleges, Abuja; Department of Biochemistry, Ahmadu Bello University, Zaria - Nigeria
2 Department of Biochemistry, Ahmadu Bello University, Zaria - Nigeria
3 Department of Medicine, Ahmadu Bello University Teaching Hospital, Shika - Nigeria

Correspondence Address:
SIR Okoduwa
Department of Biology, Nigerian Turkish international Colleges, Abuja; Department of Biochemistry, Ahmadu Bello University, Zaria - Nigeria

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Source of Support: None, Conflict of Interest: None


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Hypertension and diabetes commonly occur together. The aim of this study was to investigate the role of oxidative stress in the link among Northern Nigerians. The study involved 200 subjects (aged 20 to 79 years) divided into four groups of 50 subjects each, viz.: Non Diabetic Normotensive Persons (NDNP) as controls, while Diabetic Normotensive Patients (DNP), Non Diabetic Hypertensive Patients (NDHP) and Diabetic Hypertensive Patients (DHP) as cases. Biomarkers of oxidative stress were correlated with some trace mineral elements in serum samples collected from all the subjects. A significant (p < 0.01) negative correlation was observed between the following: CAT/MDA and Fe2+/MDA in the 3 case groups; SOD/MDA, GSH/MDA in both DNP and DHP groups; Vitamin C/MDA, Se2+/MDA and Zn2+/MDA in both NDHP and DHP groups. The negative correlation of Vitamin E with MDA was found to be significant (p < 0.01) only in DHP group. The relationship between biomarkers of oxidative stress and trace mineral elements obtained in this study is implicated in the changes in antioxidant defense system which resulted in the pathophysiologic mechanisms underlying the complication of type 2 diabetes and associated hypertension.


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