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ORIGINAL ARTICLE
Year : 2013  |  Volume : 4  |  Issue : 1  |  Page : 5

Lipid peroxidation and antioxidant status in patients with type 2 diabetes in relation to obesity in Pokhara - Nepal


1 Department of Biochemistry, Bangalore University, Bangalore - India
2 Department of Biochemistry, Dr Kamakshi Memorial Hospital, Pallaikaranai - Chennai
3 Department of Biochemistry, Manipal College of Medical Sciences and Teaching Hospital, Phulbari, Pokhara - Nepal

Correspondence Address:
N L Madhikarmi
Department of Biochemistry, Bangalore University, Bangalore - India

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Source of Support: None, Conflict of Interest: None


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Obesity is a worldwide epidemic, associated with health related problems including type 2 diabetes. Diabetes is estimated to be responsible for 3.96 million adult deaths per year globally. The aim of this study was to determine lipid peroxidation and antioxidant status in patients with type 2 diabetes at a tertiary care hospital in relation to obesity in a section of Nepali population. Obesity is determined by the body mass index (BMI). Lipid peroxidation was determined by measurement of thiobarbituric acid reactive substances (TBARS) in plasma of the patients. The antioxidant status was estimated by determining the levels of vitamin C, vitamin E and total antioxidant activity in plasma. On BMI grading 49% male patients were of normal weight, 40% pre obese and 9.4% obese I and 2% were obese II. Similarly, among female patients 42% were normal, 45% pre obese, 5% were obese I and 8% were obese II. TBARS were increased in all the male patients except obese II. Vitamin E was decreased in male patients in normal BMI group and obese I but in female patients it was decreased in all the groups. Likewise, vitamin C was increased in all the groups in male patients and in female patients it was increased in the entire group, except pre obese. Severe obesity is rather uncommon in Nepal and in the present study it was absent in patients with type 2 diabetes. Conclusively, the results showed that male patients were relatively more prone to obesity and oxidative stress than females.


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