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ORIGINAL ARTICLE
Year : 2014  |  Volume : 5  |  Issue : 1  |  Page : 4

Plasma TNF-α in obese patients with diabetes and its relation to resting metabolic rate


1 Department of Physiology, Faculty of Medicine, University of Tabuk, Tabuk - Saudi Arabia
2 Department of Physiology, Faculty of Medicine, University of Science and Technology, Khartoum - Sudan

Correspondence Address:
T H Merghani
Department of Physiology, Faculty of Medicine, University of Tabuk, Tabuk - Saudi Arabia

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Source of Support: None, Conflict of Interest: None


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Tumour necrosis factor alpha (TNF-α) exerts many biological effects on different tissues resulting in alterations in their rate of metabolism. In addition, it has direct effects on glucose homeostasis and lipid metabolism. Both plasma TNF-α and obesity are associated with insulin resistance and development of type 2 diabetes mellitus. This study was conducted to evaluate plasma TNF-α in obese patients with diabetes and to determine its relation to resting metabolic rate. Random sample of 40 obese patients with diabetes (cases) and 40 obese non-diabetic subjects (controls) were interviewed and examined clinically to exclude presence of symptoms or signs of inflammation. Haemoglobin A1c was measured for each participant using the "NycoCard Haemoglobin A1c test" (Axis -Shield/ Norway). TNF-α was measured using commercially available ELISA kits from ADIPO Bioscience/ USA. The PowerLab 8/35 with a gas analyzer (AD Instruments, Castle Hill Australia) was used for measurement of Oxygen consumption (VO2), Carbon dioxide production (VCO2) and Respiratory exchange ratio (RER). Resting metabolic rate was calculated using Weir's equation. Twenty two (55%) cases had high plasma TNF-α values (≥ 5pg/ml) whereas 31(77%) controls had lower values (p = 0.003). More than half of those with high plasma TNF-α values (18 (58%)) had abnormal haemoglobin A1c (p = 0.037). The relation between plasma TNF-α and resting metabolic rate was statistically insignificant (p = 0.104). This study showed that plasma TNF-α was significantly higher among cases compared to controls. A significant relation was found between high plasma TNF-α and poorly controlled diabetes mellitus whereas its relation to resting energy expenditure was statistically insignificant.


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