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ORIGINAL ARTICLE
Year : 2014  |  Volume : 5  |  Issue : 3  |  Page : 5

Association of high serum pro-BNP levels with severity of coronary artery disease and its limitations


Department of Medicine, College of Medicine, Diyala University, Diyala, Iraq

Correspondence Address:
A H Alhusseiny
Professor of Medicine. Department of Medicine, College of Medicine, Diyala University, Diyala, Iraq

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Source of Support: None, Conflict of Interest: None


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Myocardial ischemia is the leading cause of mortality and morbidity all over the world. Previous studies demonstrated that myocardial ischemic patients subjected to coronary angiograph were more likely to have significant high serum proBNP. The study aims to assess the level of serum proBNP levels in myocardial ischemia patients who underwent coronary angiography and to relate the proBNP levels to the severity of coronary artery disease and the components of metabolic syndrome. A total number of 128 patients admitted to the coronary angiography unit at Diyala Teaching Hospital in Diyala, were recruited in the study. Indications of coronary angiography included; Acute coronary syndrome, positive treadmill test, Stable coronary artery disease and Percutaneous coronary intervention. The severity of coronary artery disease was assessed by detecting the significant occluded lesions in the number of occluded vessels. Serum proBNP levels were measured after angiography. The results show non-significant differences in the characteristics of patients and fasting serum lipids in different categories of vessels occluded. Significant high serum proBNP levels were observed with increasing number of vessels occluded and were not seen to be related to the components of metabolic syndrome. Serum proBNP levels were significantly and inversely correlated (r =0.5, p < 0.001) with ejection fraction of left ventricle.


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