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ORIGINAL ARTICLE
Year : 2016  |  Volume : 7  |  Issue : 2  |  Page : 4

Association between serum chemerin level and severity of coronary artery disease in Egyptian patients with type 2 diabetes


1 Department of Internal Medicine, Faculty of Medicine, Alexandria University, Egypt
2 Department of Cardiology, Faculty of Medicine, Alexandria University, Egypt
3 Department of Chemical Pathology, Medical Research Institute, Alexandria University, Egypt

Correspondence Address:
M H Megallaa
Assistant Professor of Internal Medicine, Department of Internal Medicine, Faculty of Medicine, Alexandria University, Egypt

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Source of Support: None, Conflict of Interest: None


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The objective of this study was to assess the relationship between serum chemerin level and the severity of coronary artery disease (CAD) in Egyptian patients with type 2 diabetes T2DM. The study included 160 subjects; divided into 4 equal groups; T2DM patients having CAD, CAD patients without diabetes, T2DM patients without CAD and a healthy control group. Serum chemerin level, and hs-CRP were measured and the severity of CAD was assessed using SYNTAX score. Serum chemerin was significantly higher in patients with CAD (p<0.001), with no difference however between diabetic and non-diabetic subjects (p= 0.16). Our results showed a significant positive correlation between serum chemerin and waist circumference (p=0.024) as well as waist to hip ratio (p=0.044). A significant association has been observed between the severity of CAD and each of serum chemerin (p <0.001) and hs-CRP (p =0.04). We report here a positive correlation between serum chemerin level and cardio-metabolic disease, with a significant association between serum chemerin concentration and severity of CAD in Egyptian patients with T2DM.


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