Journal of Diabetology

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 10  |  Issue : 1  |  Page : 29--36

Association of Vitamin D receptor (TaqI, BsmI, and FokI) polymorphisms with prediabetes and Type 2 diabetes in Asian Indians


Visvanathan Gnanaprakash1, Dhanasekaran Bodhini1, Sekar Kanthimathi1, Kumaradas Ginivenisha1, Coimbatore Subramanian Shanthirani1, Ranjit Mohan Anjana2, Viswanathan Mohan2, Venkatesan Radha1 
1 Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India
2 Madras Diabetes Research Foundation; Dr. Mohan's Diabetes Specialties Centre, ICMR-Centre for Diabetes Advanced Research and WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Venkatesan Radha
Department of Molecular Genetics, Madras Diabetes Research Foundation, Gopalapuram, Chennai - 600 086, Tamil Nadu
India

Background: Vitamin D deficiency is known to be involved in the development of insulin resistance and type 2 diabetes (T2D), and the functions of Vitamin D are mediated through Vitamin D receptor (VDR). Only a few reports are available in the Asian Indian population highlighting the role of VDR polymorphism in diabetes. We aimed to investigate the association of VDR gene polymorphisms (TaqI, BsmI and FokI) with prediabetes (PD) and T2D and their relationship with anthropometric and biochemical parameters in Asian Indians. Subjects and Methods: In this study, 454 participants including 147 with normal glucose tolerance (NGT), 145 with PD, and 162 with T2D were enrolled in this study. Genetic variants of the VDR were genotyped using polymerase chain reaction-restriction fragment length polymorphism method. Anthropometric measurements were done in all participants. Results: The most common genotypes for TaqI, BsmI, and FokI were TC, GA, and CC, respectively. The allele distribution of TaqI differed significantly when compared between NGT and T2D group. A significant protection was shown against T2 in VDR TaqI genotypes after adjusting for age, gender, and Body Mass Index. The levels of homeostatic model assessment for insulin resistance, fasting insulin, and the waist-hip ratio were significantly higher in TT genotype when compared with TC + CC genotype of TaqI polymorphism in NGT. In PD group, the levels of serum cholesterol and low-density lipoprotein cholesterol were significantly higher in AA genotype when compared with GA + GG genotype in BsmI polymorphism. Conclusions: The study indicates VDR TaqI, and BsmI polymorphisms seem to influence anthropometric and biochemical parameters, and in particular, VDR TaqI polymorphism offers protection against T2D in Asian Indians.


How to cite this article:
Gnanaprakash V, Bodhini D, Kanthimathi S, Ginivenisha K, Shanthirani CS, Anjana RM, Mohan V, Radha V. Association of Vitamin D receptor (TaqI, BsmI, and FokI) polymorphisms with prediabetes and Type 2 diabetes in Asian Indians.J Diabetol 2019;10:29-36


How to cite this URL:
Gnanaprakash V, Bodhini D, Kanthimathi S, Ginivenisha K, Shanthirani CS, Anjana RM, Mohan V, Radha V. Association of Vitamin D receptor (TaqI, BsmI, and FokI) polymorphisms with prediabetes and Type 2 diabetes in Asian Indians. J Diabetol [serial online] 2019 [cited 2020 Aug 11 ];10:29-36
Available from: http://www.journalofdiabetology.org/article.asp?issn=2078-7685;year=2019;volume=10;issue=1;spage=29;epage=36;aulast=Gnanaprakash;type=0