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  Access statistics : Table of Contents
   2015| June-September  | Volume 6 | Issue 2  
    Online since January 13, 2017

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Setting HbA1c targets for patients with type 2 diabetes
S.M.S Islam, LB Rawal
June-September 2015, 6(2):2-2
Full text not available  [PDF]
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Prediabetes tests in predicting risk of type 2 diabetes mellitus: a meta-analysis
LI Diaz-Trejo, P Bonequi-Alvarado, NH Wacher-Rodarte, G Salinas-Escudero, GS Garcia-De-La-Torre, F Meneses-González
June-September 2015, 6(2):6-6
There is a debate concerned with the best test for prediabetes screening. The aim of this meta-analysis is to provide an estimate of the relative risk (RR) of progression to diabetes in population with impaired fasting glucose (IFG, by fasting glucose), impaired glucose tolerance (IGT, by 2 hour glucose postload) or abnormal A1c on the basis of the current literature. A search of PubMed and Ovid databases for cohort studies published between November 12, 2003-December 31, 2012 yielded 23 independent studies. We estimated overall RR for each test reported in at least five studies. Study-specific RRs were extracted and summarized using a random-effects model. Compared to normoglycemic population the overall meta-analized RR and 95% confidence interval for diabetes was: 7.47 (5.11-10.91) with 100 mg/dl cut-off point for IFG, 7.14 (4.30-11.87) with 110 mg/dl cut-off point for IFG, 3.73 (1.92-7.25) with IGT and 5.27 (2.61-10.64) with abnormal A1c. For diabetes development, we found that IFG with both 100 mg/dl (IFG100) and 110 mg/dl (IFG110) cut-off points had similar RR; nevertheless, IFG100 can identify more people in risk. The A1c test had an intermediate RR. Although the IGT had the smallest RR, it can find additional people at risk. Among the most relevant diabetes risk factors, the largest RR is for body mass index. Future researchers can explore the combination for screening with overweight or obesity and the diagnostic tests for prediabetes and their cost-effectiveness.
[ABSTRACT]   Full text not available  [PDF]
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Pulmonary aspergillosis and mucormycosis in an immunocompetent type 1 diabetic patient with past history of healed tuberculosis
BM Warpe
June-September 2015, 6(2):1-1
Invasive aspergillus and mucormycosis infection are common in immunocompromised individuals. Endobronchial fungal infections have been reported in the literature, especially in patients with diabetes complicated by diabetic ketoacidosis. The lung co-infection with aspergillus and mucormycosis in an immunocompetent case with a past history of successful anti-tubercular therapy followed by diagnosis of diabetes has not been described in the literature. We report the case of a 47 year old Indian male with type 1 diabetes who was presented with undiagnosed hemoptysis with persistent cough since two years. On work-up the chest X-ray was suggestive of reactivation tuberculosis with bronchiolitis and calcified hilar nodules. HRCT chest revealed an impression of post - Koch sequelae with fungal ball. The lung perfusion and ventilation scan revealed reduced ventilation and perfusion in the apical posterior segment of the upper right lung with a fibro-nodular scar. For definite diagnosis, CT-guided lung biopsy was done from suspected lung ball from apical portion of right lung. The biopsies were subjected to formalin fixed paraffin sectioning which revealed dual fungal colonies of aspergillosis and zygomycosis (mucormycosis). This was later confirmed by special staining with PAS. Thus definite diagnosis for complaints of the patient was obtained using the 'gold standard' diagnostic tool of histopathology. Later the patient responded successfully to anti-fungal therapy with disappearance of his complaints on follow-up.
[ABSTRACT]   Full text not available  [PDF]
  589 176 -
Features of type 2 diabetes patients with and without diagnosed diabetic retinopathy: Experiences from Vojvodina province in Serbia
DS Popovic, M Mitrovic, DT Naglic, B Vukovic, E Stokic, Z Grgic, BK Zavisic
June-September 2015, 6(2):3-3
Diabetic retinopathy is a common micro vascular complication of diabetes. The risk of diabetic retinopathy is closely associated with the type and duration of diabetes, blood glucose, blood pressure and lipid disorders. This study aims to compare features of type 2 diabetes patients with and without diagnosed diabetic retinopathy. The cross-sectional study includes 140 randomly selected type 2 diabetes patients. Patient`s general information was noted, anthropometrical measurements were conducted and blood was sampled for glucose metabolism, lipid and lipoprotein parameters and fibrinogen. 24-hour urine portion was sampled for proteinuria measurement. Fundus examination was performed by ophthalmology specialist using the 90 D biomicroscopy. For statistical analysis we used mean values, proportions, t-test, test of proportions and logistic regression. In group with diagnosed diabetic retinopathy there were 74 patients (68.92% had nonproliferative diabetic retinopathy and 31.08% had proliferative diabetic retinopathy) and most were male (p=0.0218). They were older (p=0.0009) and had longer duration of diabetes (p=0.0002). Waist circumference was significantly higher in this group (p=0.0018), and they had higher levels of proteinuria (p=0.0018). These patients more frequently used insulin (p<0.0001) and were less frequent on sulphonylureas (p=0.0030). Logistic regression showed independent association of gender, duration of diabetes, proteinuria and suplhonylureas usage with presence of diabetic retinopathy. Patients with diagnosed diabetic retinopathy are more often male. They are older and have longer duration of diabetes. Also, they are more centrally obese, have higher levels of proteinuria and are more frequent on insulin therapy and less frequent on sulphonylureas than patients without diabetic retinopathy.
[ABSTRACT]   Full text not available  [PDF]
  559 192 -
Glycemic status of neonates at a tertiary care hospital in Dhaka, Bangladesh
S Arefin, SM Shariful Islam
June-September 2015, 6(2):4-4
The objective of this study was to explore the glycemic status of neonates and its associated factors at a tertiary care hospital in Bangladesh. A cross sectional study was conducted among 114 neonates born at Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders hospital in Dhaka between March to June, 2011. Data were collected using interviewer administered close ended questionnaire through face to face interview and review of medical records by a physician adequately trained in hospital data collection. Chi-square tests and Fisher's exact tests were performed to explore the association between glycemic status of the neonates, their mothers and factors associated with neonatal glycemic status. Glycemic status of the neonates was significantly associated with gestational age (p=0.014) and birth weight (p=0.044). Glycemic sta tus of the mothers was not significantly associated with glycemic status of the neonates (p=0.409). Pre-term neonates were more hypoglycemic compared to term infants and both gestational age and birth weights were significantly associated with glycemic status of the neonates. Blood glucose should routinely be measured in all high-risk, pre-term, low birth weight neonates to prevent any adverse clinical outcome and long-term complications.
[ABSTRACT]   Full text not available  [PDF]
  537 164 -
Consistency of fasting blood glucose & oral glucose tolerance test: a hospital based study in Bangladesh
M.S.H Talukder, A.K.A Khan, S.M.K Ali, S Vaaler, A Hussain
June-September 2015, 6(2):5-5
Full text not available  [PDF]
  364 172 -