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  Indian J Med Microbiol
 

Figure 6: Photomicrographs of liver tissues of diabetic/non-diabetic rats, pre-treated with Vernonia amygdalina leaf fractions (250 mg/kg b.w.) for 28 days (H and E, stain, ×100). (a) NC: Normal control (non-diabetic group): Section shows normal histology of pancreas with high number of β-cells. (b) DC: Diabetic control: Islets show highly dispersed and morphologically deformed β-cells. (c) PC: Positive control: It has normal arrangement of islet cells and their β-cells are likened to that of the NC group. (d) VAh: Vernonia amygdalina n-hexane fraction; (e) VAc: Vernonia amygdalina chloroform fraction; (f) VAe: Vernonia amygdalina ethyl acetate fraction; (g) VAb: Vernonia amygdalina n-butanol fraction; (h) VAa: Vernonia amygdalina aqueous fraction. The VAh, VAc, VAe, VAb and VAa groups had better structural architecture compared to the DC group but morphologically distorted β-cells. The VAe and VAb show sign of regeneration but cellularity is less pronounced as compared to VAc

Figure 6: Photomicrographs of liver tissues of diabetic/non-diabetic rats, pre-treated with <i>Vernonia amygdalina</i> leaf fractions (250 mg/kg b.w.) for 28 days (H and E, stain, ×100). (a) NC: Normal control (non-diabetic group): Section shows normal histology of pancreas with high number of β-cells. (b) DC: Diabetic control: Islets show highly dispersed and morphologically deformed β-cells. (c) PC: Positive control: It has normal arrangement of islet cells and their β-cells are likened to that of the NC group. (d) VAh: <i>Vernonia amygdalina</i> n-hexane fraction; (e) VAc: <i>Vernonia amygdalina</i> chloroform fraction; (f) VAe: <i>Vernonia amygdalina</i> ethyl acetate fraction; (g) VAb: <i>Vernonia amygdalina</i> n-butanol fraction; (h) VAa: <i>Vernonia amygdalina</i> aqueous fraction. The VAh, VAc, VAe, VAb and VAa groups had better structural architecture compared to the DC group but morphologically distorted β-cells. The VAe and VAb show sign of regeneration but cellularity is less pronounced as compared to VAc