• Users Online: 456
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 1  |  Page : 4

Study of Pro-insulin Level and Its Role in a Cohort of Women with Gestational Diabetes in Alexandria, Egypt


1 Department of Internal Medicine. Alexandria University, Alexandria, Egypt
2 Department Gynecology & Obstetrics, Alexandria University, Alexandria, Egypt
3 Department Clinical Pathology Alexandria University, Alexandria, Egypt

Correspondence Address:
F E Amara
Emeritus Professor of Internal Medicine, Unit of Diabetes & Metabolism, Department of Internal Medicine, Alexandria University, Alexandria, Egypt

Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

To study the levels of serum pro-insulin or pro-insulin/insulin ratio (PIR) in women suffering from gestational diabetes mellitus (GDM), as an additional factor to their insulin resistance state during pregnancy; and to evaluate any change or reversibility of serum pro-insulin or PIR during the postpartum period. The study was conducted on 30 pregnant women in their second or third trimester and 10 age-matched non pregnant , normoglycemic women , as a reference group. The pregnant women were divided into 3 equal groups; normoglycemic women with normal oral glucose tolerance test (OGTT), obese women with GDM and lean women with GDM. Diagnostic OGTT was performed and pro-insulin levels, insulin levels, C-peptide levels, pro-insulin/insulin ratio (PIR) and insulin sensitivity were determined . These tests were repeated after 4-8 weeks of the postpartum period. Serum levels of pro-insulin and the PIR were significantly higher in obese and lean women with GDM than the control and reference groups during pregnancy and after delivery (p=0.0001). Insulin sensitivity index was significantly lower and relative resistance for insulin was significantly higher in GDM women (p<0.0001). After delivery the sensitivity index was significantly higher than during pregnancy in pregnant women, recruited in the study. C-peptide levels were significantly higher in GDM patients versus control and reference groups during pregnancy. After delivery, C-peptide levels were significantly lower in the 3 pregnant groups (p<0.0001). Women with GDM have elevated serum pro-insulin and increased PIR which might serve as a marker for the disease. Moreover, this characteristic profile might be useful for the prediction of gestational diabetes mellitus (GDM).


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1735    
    Printed150    
    Emailed0    
    PDF Downloaded210    
    Comments [Add]    

Recommend this journal