| ORIGINAL ARTICLE |
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| Year : 2011 | Volume
: 2
| Issue : 2 | Page : 4 |
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Anti-diabetic effect of Rubus ellipticus fruit extracts in alloxan induced diabetic rats
US Sharma1, A Kumar2
1 Department of Pharmacology, Sir Madanlal Institute of Pharmacy, Alampur Hauz, Agra Road. Etawah, Uttar Pradesh; Department of Pharmaceutical Science, Jodhpur National University, Jhanwar Road, Narnadi, Jodhpur, Rajasthan, India
2 Department of Pharmacy, Mahila Vishwavidyalya, Khanpur Kalan, Sonipat, Harayana, India
Correspondence Address:
U S Sharma
Department of Pharmacology, Sir Madanlal Institute of Pharmacy, Alampur Hauz, Agra Road. Etawah, Uttar Pradesh; Department of Pharmaceutical Science, Jodhpur National University, Jhanwar Road, Narnadi, Jodhpur, Rajasthan, India
 Source of Support: None, Conflict of Interest: None
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Alloxan (2, 4, 5, 6-tetraoxypyrimidine; 2, 4, 5, 6-pyrimidinetetrone) is a toxic glucose analogue, which selectively destroys insulin-producing pancreatic β-cells and causes a non-insulin-dependent diabetes mellitus (NIDDM), when administered to animal species. In this study, the protective effects of Rubus ellipticus fruit on glucose tolerance test and an alloxan induced diabetes were evaluated. An effort was also made to investigate the acute toxicity (LD50) of the extracts and the qualitative presence of phytoconstituents in the extracts. Male wistar albino rats of either sex (weighing 150-200 g) were studies for glucose tolerance test and alloxan induced diabetes. Pet.ether, ethanolic and aqueous extracts of Rubus ellipticus fruit were selected for anti-diabetic activity. Blood glucose levels were estimated at different time intervals on 1st, 4th, 7th and 15th day of the treatment with Rubus ellipticus extracts and glibenclamide. These levels were compared with these of the diabetic control group. Phytochemical analysis of Rubus ellipticus fruit revealed the presence of flavonoids, carbohydrates, steroids, tannins and phenolic compounds. In acute toxicity study, no toxic neurological and behavioral symptoms were observed for the titled plant extracts up to a dose of 2000 mg/kg. All the extracts of Rubus ellipticus fruit exhibited significant anti-diabetic effect in both the experimental models of diabetes mellitus. The results justified the traditional use of fruits in the treatment of diabetes. |
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