Journal of Diabetology

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 4  |  Issue : 2  |  Page : 5-

Insulin secretory capacity and insulin sensitivity in the normoglycemic first degree relatives of Bangladeshi subjects with prediabetes


SM Shefin1, MO Faruque2, RM Hafizur3, N Islam1, M Hossain1, S Akter4, ZA Latif2, Q Nahar1, L Ali4 
1 Department of Endocrinology and Diabetology, Ibrahim Medical College & BIRDEM Hospital, Dhaka - Bangladesh
2 Department of Biochemistry and Cell Biology, BIRDEM Hospital, Dhaka - Bangladesh
3 Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi - Pakistan
4 Department of Biochemistry and Cell Biology, BIHS, Dhaka - Bangladesh

Correspondence Address:
M O Faruque
Senior Research Officer, Department of Biochemistry and Cell Biology, BIRDEM Hospital, Dhaka - Bangladesh

Defects in insulin secretion and insulin action are common in both diabetes and prediabetes but which one is primary, is still unsettled. The present study focused on the normoglycemic first degree relatives of subjects with prediabetes to resolve this issue. Forty one first degree relatives of 14 isolated impaired fasting glucose (IFG) cases (R_IFG), 116 first degree relatives of 36 isolated impaired glucose tolerance (IGT) cases (R_IGT) and 77 first degree relatives of 20 combined IFG-IGT cases (R_IFG-IGT) and 20 healthy subjects without any family history of known diabetes or prediabetes were also included in this study. Serum insulin level was determined by enzyme linked immunosorbent assay (ELISA) method. Insulin secretory capacity (HOMA %B) and insulin sensitivity (HOMA %S) were calculated from fasting glucose and fasting insulin using HOMA-CIGMA software. Although fasting blood glucose in controls and normoglycemic first degree relatives of subjects with prediabetes were within normal range but the values were significantly higher among the normoglycemic first degree relatives of IFG, IGT and IFG-IGT, (p < 0.05) subjects compared to controls. HOMA %B in normoglycemic first degree relatives of subjects with prediabetes (R_IFG 80 ± 39, R_IGT 81 ± 34, R_IFG-IGT 90 ± 28) were significantly decreased compared to control subjects (107 ± 27). Dyslipidemia was evident in normoglycemic first degree relatives of subjects with prediabetes. Binary logistic regression analysis showed that HOMA %B was negatively associated (beta = -0.026, p = 0.009) with normoglycemic first degree relatives of subjects with prediabetes after adjusting for age, body mass index (BMI), high density lipoprotein (HDL) cholesterol, and low density lipoprotein (LDL) cholesterol. Beta cell secretory dysfunction is evident in normoglycemic first degree relatives of subjects with prediabetes in a Bangladeshi population.


How to cite this article:
Shefin S M, Faruque M O, Hafizur R M, Islam N, Hossain M, Akter S, Latif Z A, Nahar Q, Ali L. Insulin secretory capacity and insulin sensitivity in the normoglycemic first degree relatives of Bangladeshi subjects with prediabetes.J Diabetol 2013;4:5-5


How to cite this URL:
Shefin S M, Faruque M O, Hafizur R M, Islam N, Hossain M, Akter S, Latif Z A, Nahar Q, Ali L. Insulin secretory capacity and insulin sensitivity in the normoglycemic first degree relatives of Bangladeshi subjects with prediabetes. J Diabetol [serial online] 2013 [cited 2020 Oct 1 ];4:5-5
Available from: http://www.journalofdiabetology.org/article.asp?issn=2078-7685;year=2013;volume=4;issue=2;spage=5;epage=5;aulast=Shefin;type=0