Year : 2021 | Volume
: 12 | Issue : 1 | Page : 22--27
Impact of glycemic control in diabetes mellitus on management of COVID-19 infection
Sudhir Bhandari1, Govind Rankawat1, Ajeet Singh1, Vishal Gupta1, Shivankan Kakkar2
1 Department of General Medicine, SMS Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
2 Department of Physiology and Ethical Committee, SMS Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
Background: This study was undertaken to evaluate the clinical presentation, laboratory parameters, radiological imaging, management, and outcome of coronavirus disease-2019 (COVID-19) infection in patients of diabetes mellitus and its association with glycemic control. Materials and Methods: This study conducted on 80 admitted COVID-19 patients of known diabetes mellitus, who were categorized into two groups: Group 1 had patients with uncontrolled diabetes as indicated by hemoglobin A1c (HbA1c) > 8 gm% and Group 2 had patients with controlled diabetes as indicated by HbA1c < 8 gm%. Information concerning medical history, clinical manifestations, laboratory findings, radiological imaging, management, and outcome was extracted from medical records for evaluation, interpretation, and association among both the groups. Results: COVID-19 patients with uncontrolled diabetes showed a severe symptomatic presentation, excessive uncontrolled inflammatory responses, and hypercoagulable state. Total leukocyte count, neutrophil–lymphocyte ratio, serum levels of interleukin-6 (IL-6), fibrin degradation product (FDP), and D-dimer were significantly raised (P < 0.05) in case of uncontrolled diabetes as compared to controlled diabetes. Radiological findings detected by chest radiograph and computed tomography chest suggested severe lung involvement in uncontrolled diabetes. COVID-19 patients with uncontrolled diabetes required intensive treatment as compared to controlled diabetes group in terms of insulin therapy (P = 0.0226) and noninvasive ventilation (P = 0.0292). Patients with uncontrolled diabetes had higher mortality (P = 0.0375) and required prolonged hospitalization (P = 0.0479) as compared to controlled diabetes group. Conclusion: From this study, it can be concluded that uncontrolled diabetes mellitus might be responsible for an overall higher susceptibility for COVID-19 infection and severity in terms of symptomatic presentation, inflammatory storm, rapid pulmonary invasion, requirement of more intensive treatment and a poor outcome.
Dr. Govind Rankawat
Department of General Medicine, SMS Medical College and Attached Group of Hospitals, J.L.N. Marg, Jaipur 302004, Rajasthan, India.
|How to cite this article:|
Bhandari S, Rankawat G, Singh A, Gupta V, Kakkar S. Impact of glycemic control in diabetes mellitus on management of COVID-19 infection.J Diabetol 2021;12:22-27
|How to cite this URL:|
Bhandari S, Rankawat G, Singh A, Gupta V, Kakkar S. Impact of glycemic control in diabetes mellitus on management of COVID-19 infection. J Diabetol [serial online] 2021 [cited 2021 Jan 17 ];12:22-27
Available from: https://www.journalofdiabetology.org/article.asp?issn=2078-7685;year=2021;volume=12;issue=1;spage=22;epage=27;aulast=Bhandari;type=0